MOTS-c (Mitochondrial-Derived Peptide) | 40mg

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a groundbreaking peptide that represents a paradigm shift in biohacking. Unlike most peptides encoded in your cell's nucleus, MOTS-c is encoded directly within the mitochondrial DNA. It acts as a systemic "metabolic master switch," regulating how your entire body processes energy, burns fat, and responds to physical stress.

Beyond the Treadmill: Why MOTS-c is Revolutionary
MOTS-c is essentially "exercise in a vial." It mimics the metabolic signals typically generated by high-intensity physical activity, making it a cornerstone for those looking to optimize body composition and longevity.

The Key Benefits for Research:

AMPK Activation: MOTS-c is a potent activator of the AMPK pathway—the body’s "fuel sensor." This triggers the uptake of glucose and the oxidation of fatty acids, effectively turning your cells into fat-burning furnaces.

Reversal of Metabolic Aging: As we age, MOTS-c levels naturally decline. Supplementing this peptide helps restore youthful insulin sensitivity and glucose metabolism, combating the "middle-age spread" and metabolic slowdown.

Enhanced Physical Performance: In research models, MOTS-c has been shown to significantly increase running capacity and heat tolerance by improving skeletal muscle coordination and energy output.

Mitochondrial Biogenesis: It doesn't just make your current mitochondria work harder; it signals your body to create new mitochondria, increasing your total cellular energy capacity (ATP production).

Bone Density & Joint Support: Emerging research suggests MOTS-c promotes the differentiation of osteoblasts (bone-forming cells), supporting structural integrity alongside metabolic health.

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino acid peptide that represents a unique class of signaling molecules encoded within the mitochondrial DNA rather than the cell nucleus. In metabolic research, MOTS-c is utilized as a primary tool for investigating the mitochondrial-to-nuclear signaling axis and the regulation of systemic energy homeostasis.

The Science of Mitochondrial Signaling

MOTS-c is a potent metabolic regulator that operates primarily through the AMPK (AMP-activated protein kinase) pathway. Researchers utilize this peptide to study the cellular "fuel sensor" mechanism and the subsequent modulation of glucose and lipid metabolism in laboratory models.

Primary Areas of Laboratory Interest:

• AMPK Pathway Activation: Research focuses on MOTS-c’s role as a potent activator of AMPK, observing the subsequent increase in glucose uptake and fatty acid oxidation markers within in vitro cellular assays.

• Metabolic Homeostasis & Insulin Sensitivity: Laboratory studies investigate the compound’s ability to influence insulin signaling pathways and glucose disposal rates, particularly in models of age-related metabolic decline.

• Skeletal Muscle Energy Flux: MOTS-c is a subject of interest in research regarding skeletal muscle coordination and energy output, specifically focusing on its impact on heat tolerance and running capacity in experimental models.

• Mitochondrial Biogenesis: Studies examine the peptide’s ability to signal the creation of new mitochondria, investigating the expansion of total cellular energy capacity and ATP production markers.

• Osteoblast Differentiation: Emerging research utilizes MOTS-c to observe the differentiation of bone-forming cells, studying its impact on structural integrity and the maintenance of bone density in metabolic research.

⚠️ Research Use Only Disclaimer
This product is strictly for laboratory research purposes only. MOTS-c is not approved for human consumption, medical use, or the treatment of any disease. It has not been evaluated by the FDA. Any use of this product in a clinical or human setting is strictly prohibited. The purchaser is responsible for ensuring compliance with all local laws and laboratory safety protocols.

In Relation to Cartridge and Pen Orders

 The product is reconstituted with 3ml BAC on day of dispatch to maximise potency by the time it arrives. To keep costs minimal, we do not ship with cool packs the product should maintain potency at room temperature for up to 21 days, and should be stored refrigerated as soon as you receive.